Dapoxetine: What is it? Drug interactions, side effects, dosage, and best uses

Introduction to Dapoxetine

Dapoxetine is a rapidly absorbed oral medication that is primarily recommended to treat men’s premature ejaculation (PE). It is marketed as Everlong tablets. It is classified as an SSRI (selective serotonin reuptake inhibitor). Dapoxetine is specially designed for immediate usage before to sexual activity, unlike other SSRIs used to treat depression. Its short active period and fast-acting effects make it ideal for men who want better control over ejaculation on demand. Raising serotonin levels in the brain prolongs the period before climax during sexual activity and aids in better control over ejaculation.

Dapoxetine is the first and only medication specifically licensed for premature ejaculation in several countries. Eli Lilly created dapoxetine, which the FDA (Food and Drug Administration) of the United States approved in 2004. Dapoxetine may be a safe and efficient method to enhance your sexual health and quality of life. If you’re having problems with premature ejaculation (PE).

 

یورلونگ ٹیبلٹ مردوں کے لیے قبل از وقت انزال (جلدی فارغ ہونے) کے مسئلے کا مؤثر علاج ہے۔ یہ گولی ہمبستری سے 1 سے 2 گھنٹے پہلے لی جاتی ہے تاکہ ٹائمنگ میں بہتری آئے۔ اس سے خود اعتمادی بحال ہوتی ہے اور ازدواجی زندگی خوشگوار بنتی ہے۔ استعمال سے پہلے کسی مستند ڈاکٹر سے مشورہ ضرور کریں۔

 

Dapoxetine for Premature Ejaculation: How Does It Work?

Dapoxetine functions by raising serotonin levels, which are a natural brain chemical that is important for mood and sexual function. This prescription falls under the category of drugs known as selective serotonin reuptake inhibitors, or SSRIs for short.

Men who have premature ejaculation (PE) may experience an early climax due to low or weak serotonin levels and signals. By preventing its reabsorption (reuptake) in the brain, dapoxetine increases serotonin activity and prolongs the effects of serotonin on the neurons that regulate ejaculation.

This activity is beneficial:

• Ejaculation delay
• Increase ejaculation control
• Minimize any personal anguish or annoyance associated with PE
• Boost your level of sexual satisfaction

Unlike other SSRIs, dapoxetine is fast-acting and rapidly excreted from the body, which makes it appropriate for on-demand use (one to three hours before to sexual activity) as opposed to daily treatment.

How Uses of Dapoxetine for Premature Ejaculation?

A fast-acting drug from the Selective Serotonin Reuptake Inhibitor (SSRI) class, dapoxetine (Everlong tablets) is authorized to treat premature ejaculation (PE) in men aged 18 to 64. It is perfect for on-demand sexual health support because it acts fast and is used as needed rather than daily like other antidepressants.

1. Premature ejaculation (PE) treatment

Dapoxetine is primarily and most significantly used to treat premature ejaculation, a common male sexual dysfunction in which ejaculation happens too rapidly (often within 1-2 minutes of penetration), leading to relationship problems, stress, and dissatisfaction. Dapoxetine helps by raising serotonin levels in the brain, which delays the ejaculatory reflex.

• Extended sexual activity
• Boost climax control
• Boost general sexual satisfaction

2. Improves Control of Ejaculation

Men with PE frequently have difficulty controlling their ejaculation, which makes them feel powerless. By enhancing neurological responsiveness and control, dapoxetine helps men better time their ejaculations and make the encounter more satisfying for both parties.

3. Enhances Self-Esteem and Sexual Confidence

Emotional distress, shame, and low self-esteem might result from premature ejaculation. By granting men more authority over their sexual behavior, Dapoxetine:

• restores self-assurance in close relationships
• lessens the anxiety associated with sexual failure
• improves a partner’s emotional connection

4. Lessens Performance and Psychological Anxiety

Performance anxiety is one of the primary causes and consequences of premature ejaculation. The serotonin-related effects of dapoxetine not only aid postpone ejaculation but also have a mildly relaxing impact, lowering:

• Anxiety during sexual activity
• psychological strain brought on by previous setbacks
• Tension that is anticipated before closeness

5. Supports Acquired and Lifelong PE

Dapoxetine works well for controlling

• PE is a lifelong condition that begins with a man’s first sexual encounter.
• Later in life, acquired PE might arise as a result of stress, illnesses, or emotional problems.

6. Promotes General Sexual Health

Dapoxetine’s primary function is to postpone ejaculation, however it also indirectly promotes long-term sexual health by:

• Encouraging contentment and relaxation during intimacy
• lowering marital stress and partner discontent while promoting a healthy sexual practice

Dapoxetine’s Function in Long-Term Sexual Health

In addition to being an effective short-term solution, dapoxetine (Everlong tablet) also contributes to long-term sexual health by:

• Improving blood flow and hormone equilibrium
• Increasing self-esteem and mood
• promoting fertility and reproductive health

When Used Before Sex:

• Because dapoxetine takes one to three hours to start working, it is best to take it before you intend to have sex. Many people find it safe because it doesn’t accumulate in their system and has fewer negative effects due to its rapid excretion from the body.

For Extended Use:

• Dapoxetine may be taken on a regular basis, but only under a doctor’s supervision, if a patient has experienced frequent premature ejaculation. This promotes better control during intercourse and helps maintain stable serotonin levels.

How to Take and Dosage Dapoxetine

Fast-acting oral dapoxetine should be taken as prescribed by a physician, usually as needed prior to intercourse. Unlike several other drugs, it is not intended for constant daily use.

How Dapoxetine Is Taken

• To prevent lightheadedness or an abrupt drop in blood pressure, take with a full glass of water.
• Though it’s preferable to avoid heavy or fatty meals as they may impede absorption, it can be taken with or without food.
• The pill should be swallowed whole with a full glass of water; do not chew, break, or crush it.
• When taking Dapoxetine, stay away from alcohol as it may raise the chance of adverse effects like sleepiness or fainting.

When to Take Dapoxetine

• You should take the tablet one to three hours prior to your intended sexual activity for optimal effects.
• Dapoxetine is typically used on an as-needed basis unless a doctor advises otherwise.
• Don’t take more than one dose in a 24-hour period.

Suggested Dosage

• 30 mg should be given one to three hours prior to anticipated sexual activity as the starting dose.
• If Required: Under medical supervision, the dosage may be raised to 60 mg if 30 mg is well tolerated but insufficiently effective.
• Maximum Dosage: Avoid taking multiple doses in a 24-hour period.

Avoid Using If

• You are either younger than 18 or older than 65.
• You take antidepressants, MAO inhibitors, or other SSRIs.
• Before taking Dapoxetine, let your doctor know if you have a history of seizures, liver disease, or cardiac problems.
• You treat your chest pain with nitrate drugs.

Crucial Safety Advice

• Steer clear of alcohol because it can exacerbate symptoms like lightheadedness, fainting, or poor judgment.
• Avoid using heavy machinery or driving since dapoxetine can make some people feel lightheaded or faint.
• Drink plenty of water to stay hydrated, particularly if you perspire a lot or feel dizzy.

Final Note

Dapoxetine should only be taken as directed by a physician. Always consult your doctor before changing how often or how much you take your medication.
If the scheduled time for sexual activity has passed and you have forgotten to take your medication, just skip it. Don’t take two doses to its  make up for it.

Adverse Effects of Dapoxetine

Like all drugs, dapoxetine is generally safe and well-tolerated, but some people may experience negative side effects. In rare instances, these symptoms may be severe, although they can also be mild to moderate. Users can make better decisions and know when to need medical treatment if they understand them.

Less frequent but less dangerous side effects

• Vision blur
• Feeling tingly or numb
• Elevated pulse rate, or palpitations
• mild restlessness or anxiousness
• sleepiness or yawning

Serious side effects are uncommon but necessitate prompt medical care.

Contact a Doctor if you observe any of the following symptoms:

• Lightheadedness or extreme vertigo
• Unusual heartbeat or chest pain
• Convulsions
• Suicidal thoughts or severe mood swings
• Symptoms of an allergic reaction include breathing difficulties, facial, tongue, or throat swelling, rash, and itching.

Final Advice

To reduce adverse effects:

• Follow the dosage instructions.
• Steer clear of booze.
• Dosing more than thrice in a 24-hour period may increase the likelihood of adverse consequences.
• Drink plenty of water to keep hydrated.

The majority of men who use dapoxetine either have no negative effects at all or very minor, transient ones. However, being knowledgeable can guarantee safe and efficient use.

Dapoxetine: Warnings & Precautions

Premature ejaculation (PE) in men is treated with the prescription drug dapoxetine. When used properly, it is usually safe and effective, but there are several warnings and measures that must be taken to prevent unintended side effects and guarantee the greatest possible result.

Precautions

Verification of Medical History

Inform your doctor before starting Dapoxetine if you have a history of:

• cardiac issues including a recent heart attack, heart failure, or an irregular pulse.
• The way your body metabolizes the medicine may be affected by liver or kidney issues.
• mental health issues such as suicide thoughts, bipolar illness, depression, or anxiety.
• Dapoxetine may reduce the threshold for seizures or epilepsy.
• low blood pressure, especially if you’ve had fainting before.

Avoid Alcohol

• Alcohol consumption increases the risk of adverse consequences such as fainting, sleepiness, and dizziness.
• Alcohol and Dapoxetine together can severely reduce blood pressure and impair cognitive function.

Use caution when operating machinery or driving.

• Dapoxetine may cause sudden lightheadedness, blurred vision, or sleepiness.
• After taking this drug, avoid engaging in activities that need total mental concentration.

Hydration Is Important

• Dehydration might increase the risk of fainting and low blood pressure. Drink a lot of water, particularly if you’re exercising or in hot weather.

Important Warnings

Fainting Risk

• When rising up fast, dapoxetine can induce abrupt reductions in blood pressure.
• This can be prevented by taking the medication with a full glass of water and then sitting or lying down for a bit.

Mood swings and suicidal thoughts

• Dapoxetine can occasionally result in mood swings, sadness, or suicidal thoughts, particularly in people who have a personal or familial history of mental illness.
• If you have significant mood swings or suicidal thoughts, stop taking the medication and see your doctor.

Drug Dependency

• You should not take dapoxetine every day unless your doctor specifically instructs you to do so. It is intended to be used as needed, usually one to three hours prior to intercourse.

Not for Specific Groups

• For Women Dapoxetine is not been approved for use by female patients.
• It is not advised for kids and teenagers under the age of 18.
• Men over 65: Use only under close medical supervision and with extreme caution.

Avoid Using This with Some Medications

Avoid Dapoxetine if you are taking:

• Other antidepressants, SNRIs, or SSRIs
• MAOIs, or monoamine oxidase inhibitors,
• Thioridazine is an example of an antipsychotic drug.
• Sildenafil, also referred to as Viagra, and related drugs are used to treat erectile dysfunction.

Dapoxetine Drug Interactions

It’s critical to realize that interactions between some medications can alter their effectiveness or raise the risk of adverse effects. This occurs when a medication’s breakdown or blood concentration is impacted by another substance. Dapoxetine interacts with the following medications:

Monoamine oxidase inhibitors, or MAOIs:

Serious side effects, such as serotonin syndrome, can occur when Dapoxetine is taken with MAO inhibitors, which are prescribed for depression or Parkinson’s disease. MAO inhibitors (MAOIs) should not be taken with Dapoxetine, and MAOIs should not be taken for at least 14 days prior to or following Dapoxetine use.

Thioridazine:

Because of its effects on electrical conduction in the heart, thioridazine, an antipsychotic, and dapoxetine can cause serious cardiac rhythm abnormalities.

Other antidepressants and SSRIs/SNRIs:

Serotonin syndrome, a potentially fatal illness, can be made more likely by concurrent use of other antidepressants such as fluoxetine, sertraline (SSRIs), or venlafaxine (SNRIs). You should always let your doctor know if you take antidepressants.

Inhibitors of CYP3A4:

Drugs that block the CYP3A4 enzyme, such as erythromycin, ritonavir, and ketoconazole, may raise blood levels of Dapoxetine. This may make adverse consequences like lightheadedness or fainting more likely.

Inducers of CYP3A4:

Dapoxetine’s effectiveness may be diminished by medications that speed up its metabolism, such as rifampin, carbamazepine, and phenytoin. When taking these drugs together, dosage adjustments may be necessary.

Erectile dysfunction medications, or PDE5 Inhibitors:

Dapoxetine may cause an unsafe reduction in blood pressure when used with vardenafil, tadalafil (Cialis tablet), or sildenafil (Viagra). When taking these drugs together, careful observation is advised.

Anticoagulants and NSAIDs:

The risk of bleeding may rise if Dapoxetine is taken with medications such as warfarin, ibuprofen, or aspirin. Care and close observation are necessary, especially when using for an extended period of time.

Alcohol

When taking this drug, avoid drinking alcohol as it may raise the risk of adverse effects like fainting, sleepiness, and dizziness.

In conclusion

A dependable and successful treatment for early ejaculation is dapoxetine. By raising serotonin levels, it helps postpone ejaculation, boosts confidence, and improves control during sexual activity. It supports improved sexual performance and enjoyment and is ideal for on-demand use due to its rapid start and minimal danger of negative effects.